Extraction of starfish saponins by supercritical extraction equipment
Extraction of starfish saponins by Supercritical co2 fluid extraction equipment
Starfish and sea cucumbers and sea urchins are equivalent to echinoderms. They usually have five wrists, but there are also four or six, flat and mostly star-shaped.
In recent years, through continuous research on the starfish, more than a dozen bioactive substances have been discovered from the starfish, including saponins, sterols, alkaloids and so on. Among them, saponins are widely studied, and starfish saponins have various pharmacological activities: hemolytic activity, tumor cytotoxicity, and antiviral action.
At present, the traditional starfish saponin extraction process is mainly a dilute alcohol extraction method, but the process is long and complicated, and the extraction rate is low. The saponin component is easily decomposed during a long heating process, and the physiological activity is lowered.
Supercritical CO2 extraction equipment is a process in which carbon dioxide is used as a solvent in a supercritical state (temperature: 31.3 ° C, pressure: 7.15 MPa), and its separation property is extracted by utilizing its high permeability and high solubility. The supercritical carbon dioxide extraction technology has a good environment, safe operation, no harmful residue, high product quality and maximum biological activity. In turn, it affects the efficacy of the drug and causes losses to the enterprise.
We conducted a small-scale experiment on the supercritical CO2 extraction of starfish saponins. A supercritical fluid extraction process of saponin was designed and developed based on the characteristics of starfish saponin. The study on the extraction of starfish saponins by supercritical CO2 using starfish as raw material was completed. Firstly, the starfish was freeze-dried and pulverized. The effects of extraction temperature, extraction pressure, CO2 flow rate and additives on the extraction rate were studied. The process research was carried out with the comprehensive index of yield and purity as the evaluation standard. Therefore, it can reduce costs, save time and bring greater economic benefits for enterprises.